Specific binding sites in collagen for integrins and use...

Details Specific binding sites in collagen for integrins and use... Specific binding sites in collagen for integrins and use...

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2620465

The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.

L'invention concerne une séquence de liaison à affinité élevée dans le collagène de type III destinée à des domaines I d'intégrine de liaison du collagène. L'invention concerne des procédés utilisés pour caractériser la séquence, les peptides comprenant cette séquence et l'utilisation des peptides dans la réalisation de l'adhésion cellulaire. L'invention concerne, en outre, des procédés permettant d'identifier des inhibiteurs d'intégrine spécifiques, des séquences de ces inhibiteurs et l'utilisation de ceux-ci dans l'inhibition d'états pathophysiologiques pouvant apparaître en raison de l'interaction intégrine-collagène.

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