Specific cd4+cd25+ regulatory t cells for haematopoietic...

Details Specific cd4+cd25+ regulatory t cells for haematopoietic... Specific cd4+cd25+ regulatory t cells for haematopoietic...

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 35/30 (2006.01) A61P 37/06 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2643580

The invention relates to a pharmaceutical composition comprising CD4+ CD25+ regulatory T cells specific for at least one minor histocompatibility antigen, and also to stem cells, advantageously haematopoietic stem cells, carrying at least said antigen. Such a composition can be used as a medicament for increasing the immune tolerance of a histocompatible host.

L'invention concerne une composition pharmaceutique comprenant des cellules T in régulatrices CD4+ CD25+ spécifiques d'au moins un antigène mineur au d'histocompatibilité, ainsi que des cellules souches avantageusement hématopoïétiques porteuses d'au moins ledit antigène. Une telle composition peut être utilisée comme médicament pour augmenter la tolérance immunitaire d'un hôte histocompatible.

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