Specific detection of cell surface receptor leukocyte...

Details Specific detection of cell surface receptor leukocyte... Specific detection of cell surface receptor leukocyte...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132213

A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-I (sLAM-1) by Western blot and ELISA analysis are disclosed, Also disclosed are methods for the specific detection of cell-surface bound LAM-1 in the presence of shed LAM- 1 and for immunotherapy using monoclonal antibodies reactive with cell-surface bound LAM-1 but not reactive with shed LAM-1.

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