Specific fusion nucleic acids and proteins present in human...

Details Specific fusion nucleic acids and proteins present in human... Specific fusion nucleic acids and proteins present in human...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 9/22 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2177957

The present invention is based on the identification and sequence determination of fusion proteins generated by translocation which is present in t(2;5) lymphoma cells. Using either the amino acid or nucleic acid sequences of the fusion proteins disclosed herein, the present invention provides methods of detecting and treating t(2;5) lymphoma.

L'invention porte sur l'identification, et la détermination des séquences, de protéines fusionnées produites par translocation et présentes dans les cellules des lymphomes t(2;5). L'invention fournit des méthodes de détection et de traitement du lymphome t(2;5) utilisant les séquences susdites d'acides aminés ou d'acide nucléique de ces protéines fusionnées.

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