Specific inhibition of dihydrofolate reductase and compounds...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01)

Patent

CA 2095518

2095518 9208461 PCTABS00013 Compounds derived from pyrimidines having improved activity against fungi such as Pneumocystis carinii, and improved selectivity for P. carinii dihydrofolate reductase over human dihydrofolate reductase, are disclosed. P. carinii pneumonia is advantageously treated with the disclosed compounds.

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