Specific inhibitors of dna methyltransferase enzyme

Details Specific inhibitors of dna methyltransferase enzyme Specific inhibitors of dna methyltransferase enzyme

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2256305

The invention provides novel mechanism-based inhibitors of DNA methyltransferase enzyme, and diagnostic and therapeutic uses for the same. The novel inhibitors according to the invention form stable, noncovalent complexes with DNA methyltransferase enzyme in a manner which is independent of S-adenosylmethionine.

L'invention concerne de nouveaux inhibiteurs d'ADN méthyltransférase basés sur un mécanisme et leurs utilisations diagnostiques et thérapeutiques. Les nouveaux inhibiteurs de l'invention forment des complexes stables non covalents avec une ADN méthyltransférase d'une manière indépendante de S-adénosyleméthyonine.

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