C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/04 (2006.01) A61K 31/365 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2581375
Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.
L'invention concerne des lactones d'acide résorcyclique comportant une double liaison en position C5-C6 cis et une cétone en C7, ainsi que d'autres composés pouvant former un produit d'addition de Michael, qui constituent des inhibiteurs puissants et stables d'un sous-groupe de protéines kinases comportant un résidu cystéine spécifique au niveau de leur site de liaison ATP.
Hutchinson C. Richard
Lau Janice
Reid Ralph C.
Santi Daniel V.
Sundermann Kurt F.
Fetherstonhaugh & Co.
Kosan Biosciences Incorporated
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