Specific pancreatic lipase inhibitors and their applications

Details Specific pancreatic lipase inhibitors and their applications Specific pancreatic lipase inhibitors and their applications

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) C12N 9/20 (2006.01)

Patent

CA 2277778

The invention concerns specific pancreatic lipase inhibitors and their applications in the treatment and prevention of cardiovascular diseases, of hyperlipemia and of obesity, as well as diagnostic reagent and as regulating agent in a process of controlled lipolysis of triglycerides. Said inhibitors correspond in particular to a peptide consisting of a C-terminal fragment of pancreatic lipase including the recognition site of a colipase.

Inhibiteurs spécifiques de la lipase pancréatique et leurs applications dans le traitement et la prévention des maladies cardiovasculaires, de l'hyperlipémie et de l'obésité, ainsi qu'en tant que réactif de diagnostic et en tant qu'agent de régulation dans un procédé de lipolyse ménagée de triglycérides. Lesdits inhibiteurs correspondent notamment à un peptide constitué d'un fragment C-terminal de lipase pancréatique incluant le site de reconnaissance d'une colipase.

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