Sperm antigen corresponding to a sperm zona binding protein...

Details Sperm antigen corresponding to a sperm zona binding protein... Sperm antigen corresponding to a sperm zona binding protein...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 7/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2177464

The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigeenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.

L'invention concerne de l'ADN codant une protéine Sp 17 de mammifère, plus particulièrement la protéine Sp 17 humaine ou des peptides antigéniques constituant des fragments de cette dernière, ainsi que lesdits fragments antigéniques. Ces protéines et peptides sont utiles en tant qu'agents immunocontraceptifs et/ou pour le diagnostic de la stérilité auto-immune. Des cellules hôtes non virulentes exprimant les protéines ou peptides antigéniques et utiles en tant qu'agents immunocontraceptifs sont également décrites.

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