C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 15/08 (2006.01) A61P 15/16 (2006.01) A61P 15/18 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2462670
Nucleic acid and protein sequences relating to a cation channel which is sperm- specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.
La présente invention concerne des séquences d'acides nucléiques et de protéines se rapportant à un canal cations qui est spécifique du sperme (CatSper2). La protéine CatSper2 s'avère exprimée de façon spécifique dans le sperme. L'invention concerne plus particulièrement des acides nucléiques, des vecteurs, des cellules transformées, des animaux transgéniques, des polypeptides, ainsi que des anticorps se rapportant au gène et à la protéine de CatSper2. L'invention concerne également des procédés de fertilisation et de contraception in vitro, des procédés d'identification de modulateurs de l'activité de CatSper2, des procédés de génotypage de sujet par rapport au CatSper2, des procédés de diagnostic et de traitement de troubles à médiation du CatSper2, et notamment de l'infertilité, ainsi que des procédés de nature entrprenoriale et commerciale gravitant autour de ces troubles à médiation du CatSper2.
Clapham David E.
Garbers David L.
Quill Timothy A.
Ren Dejian
Board Of Regents The University Of Texas System
Children's Medical Center Corporation
Mbm Intellectual Property Law Llp
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