Spermine chemically linked to lipids and cell-specific...

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 9/127 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2487274

This invention features methods and compositions for delivery of nucleic acids (e.g., DNA, RNA, PNA, and hybrids thereof) to cells. The nucleic acid delivery complexes of the invention permit biologically active nucleic acids to be delivered to cells and organisms in vitro and in vivo in a manner and form that allows the nucleic acids to carry out their desired biological function.

L'invention concerne des procédés et des compositions destinés à administrer des acides nucléiques (par exemple, ADN, ARN, ANP, et des hybrides de ces composés) à des cellules. Les complexes d'administration des acides nucléiques de l'invention permettent d'administrer des acides nucléiques biologiquement actifs à des cellules et à des organismes <i>in vitro </i> et <i>in vivo </i>, d'une manière et sous une forme permettant aux acides nucléiques de réaliser leurs fonctions biologiques recherchées.

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