Spex compositions and methods of use

Details Spex compositions and methods of use Spex compositions and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 1/22 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2523025

The present invention provides novel polypeptides and other factors identified as being expressed in spleen tissue and related to lymphocyte activity and the immune response. These compounds are referred to herein as SPEX compounds. Human and murine homologues of SPEX polypeptides and polynucleotides are provided including two murine alleles. The invention further provides polynucleotides encoding the polypeptides and complementary nucleic acid sequences thereof. Also provided are immunogens, expression vectors, and antibodies related to the SPEX polypeptides and polynucleotides. The present invention discloses the use of anti-SPEX antibodies in the regulation of lymphocyte activity and the regulation of the immune response.

La présente invention a trait à de nouveaux polypeptides et d'autres facteurs identifiés comme étant exprimés dans le tissu de la rate et liés à une activité lymphocytaire et à la réponse immunitaire. Ces composés sont ici désignés composés SPEX. L'invention a également trait à des homologues humains et murins des polypeptides et des polypeptides SPEX comportant deux allèles. L'invention a trait en outre à des polynucléotides codant pour les polypeptides et des séquences d'acide nucléique complémentaires de ceux-ci. L'invention a trait également à des immunogènes, des vecteurs d'expression, et des anticorps liés aux polypeptides et polynucléotides SPEX. Enfin la présente invention a trait à l'utilisation d'anticorps SPEX dans la régulation de l'activité lymphocytaire et la régulation de la réponse immunitaire.

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