Spherical linear polysaccharide-containing microparticles

Details Spherical linear polysaccharide-containing microparticles Spherical linear polysaccharide-containing microparticles

C - Chemistry, Metallurgy

08

J

C08J 3/14 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2302346

The invention relates to microparticles having a uniform spherical shape and showing a very narrow dimensional distribution. These microparticles are fully or partly composed of a linear water insoluble polysaccharide, preferably 1,4- .alpha.-D-polyglucan, and they can contain other, preferably biodegradable, polymers and/or active ingredients. They can, inter alia, be used for the controlled release of active ingredients. The are produced by dissolving the 1,4-.alpha.-D-polyglucan or said polysaccharide in a solvent, mixing the solution with a precipitating agent, cooling the mixture and separating the formed particles.

L'invention concerne des microparticules de forme sphérique régulière, dont la distribution dimensionnelle est très étroite. Elles sont constituées complètement ou partiellement d'un polysaccharide linéaire non soluble dans l'eau, de préférence de 1,4-.alpha.-D-polyglucane, et peuvent contenir d'autres polymères et/ou principes actifs, en particulier biodégradables. Elles peuvent, entre autres, être utilisées pour la libération contrôlée de principes actifs. Elles sont produites par dissolution de 1,4-.alpha.-D-polyglucane ou dudit polysaccharide dans un solvant, introduction de la solution dans un précipitant, refroidissement du mélange et séparation des particules formées.

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