Spheron components useful in determining compounds capable...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2526654

The present invention relates to racemized proteins and racemized protein components of spherons that are useful for identifying compounds capable of preventing and/or ameliorating symptoms of Alzheimer's Disease and/or dementia associated with cerebral amyloidosis. The invention also relates to the compounds identified by the methods, and methods of treating and/or ameliorating symptoms of Alzheimer's Disease and/or dementia associated with cerebral amyloidosis. The invention also relates to methods of making an Alzheimer's Disease or dementia associated with cerebral amyloidosis animal model or test animal, the animal model produced therefrom, and to a method of using the animal model to screen for effective therapies.

La présente invention concerne des protéines racémisées et des constituants de protéines racémisées de sphérons utiles pour identifier des composés permettant de prévenir et/ou d'atténuer les symptômes de la maladie d'Alzheimer et/ou de la démence associée à l'amyloïdose cérébrale. Elle concerne également les composés identifiés au moyen des méthodes de l'invention, ainsi que des méthodes destinées à traiter et/ou atténuer les symptômes de la maladie d'Alzheimer et/ou de la démence associée à l'amyloïdose cérébrale. L'invention se rapporte en outre à des méthodes de production d'un animal de laboratoire ou d'un modèle animal de la maladie d'Alzheimer ou de la démence associée à l'amyloïdose cérébrale, le modèle animal ainsi produit, ainsi qu'une méthode d'utilisation de ce modèle animal pour la recherche de traitements efficaces.

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