A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2360418
A self-emulsifying system which comprises: I) a first portion comprising microcrystalline cellulose; and II) a second portion comprising: (A) up to 200 %, based on the weight of the first portion, of an oily substance; (B) between 2 and 100 %, based on the weight of the first portion, of a surfactant; and (C) between 2 and 1000 %, based on the weight of the oily substance and the surfactants, of water; wherein the total weight of the oily substance and the surfactant is between 2 and 200 % of the first portion, is disclosed, which is particularly useful for providing solid dosage forms of hydrophobic or water sensitive agents when dried or extruded and spheronised.
La présente invention concerne un système auto-émulsionnant comprenant: I) une première partie constituée de cellulose microcristalline, et II) une seconde partie comprenant: (A) jusqu'à 200 %, par rapport au poids de la première partie, d'une substance huileuse, (B) entre 2 et 100 %, par rapport au poids de la première partie, d'un agent tensioactif, et (C) entre 2 et 1000 % d'eau, par rapport au poids de la substance huile et des agents tensioactifs. Dans ce système, le poids total de substance huileuse et d'agent tensioactif est compris entre 2 et 200 % du poids de la première partie. Le système de l'invention permet particulièrement d'obtenir des formes de dosage solide d'agents hydrophobes ou sensibles à l'eau sous forme sèche ou extrudée et sphéronisée.
Booth Steven William
Clarke Ashley
Newton John Michael
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
School Of Pharmacy University Of London
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