Sphingoid polyalkylamine conjugates for vaccination

Details Sphingoid polyalkylamine conjugates for vaccination Sphingoid polyalkylamine conjugates for vaccination

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2528402

The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.

La présente invention se rapporte à l'utilisation d'un conjugué sphingoïde-polyalkylamine en tant qu'agent de capture de molécules actives biologiquement, telles que des antigènes. Dans un mode de réalisation particulier, les sphingoïdes-polyalkylamines sont utilisés pour la préparation d'une composition pharmaceutique permettant de moduler la réponse immunitaire d'un sujet. L'invention se rapporte également à des procédés de modulation de la réponse immunitaire d'un sujet au moyen des complexes de ce conjugué comprenant le conjugué sphingoïde-polyalkylamine combiné à une molécule biologiquement active capable de moduler une réponse immunitaire d'un sujet. L'invention se rapporte également à des compositions comprenant ce conjugué ainsi qu'à des trousses faisant usage dudit conjugué. Un conjugué préféré conforme à l'invention est la spermine N-palmitoyle D-érythrosphingosyl-1-carbamoyle.

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