Sphingolipids

Details Sphingolipids Sphingolipids

C - Chemistry, Metallurgy

07

C

C07C 215/68 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/66 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07C 215/10 (2006.01) C07C 215/24 (2006.01) C07C 215/28 (2006.01) C07C 215/36 (2006.01) C07C 233/43 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 311/04 (2006.01) C07F 9/10 (2006.01) C07F 9/113 (2006.01)

Patent

CA 2461801

The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (I) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingolipids and thus in the treatment of lipid storage diseases. The compounds of formula (I) can also be used for the treatment of cancerous diseases and for killing of wild type and drug-resistant cancer cells.

L'invention concerne des composés représentés par la formule (I) et des compositions pharmaceutiques contenant ces composés. Lesdits composés sont des inhibiteurs d'enzymes variées associées à des lipides. On peut les utiliser pour réduire l'accumulation de sphingolipides et donc pour traiter des maladies associées au stockage de lipides. On peut également les utiliser pour traiter des maladies cancéreuses et pour tuer des cellules cancéreuses de type sauvage résistant aux médicaments.

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