C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) A61K 31/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/88 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2305686
Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
L'invention concerne des compositions, des procédés et des trousses utiles pour diagnostiquer et traiter un cancer. Des compositions thérapeutiques peuvent comporter des agents modulant l'expression ou l'activité d'une sphingosine-1-phosphate lyase (SPL). Ces compositions peuvent être administrées à un mammifère atteint d'un cancer. Des méthodes diagnostiques et des trousses peuvent employer un agent convenant pour détecter des altérations de SPL endogène. Ces méthodes et ces trousses peuvent être utilisées pour détecter la présence d'un cancer, ou pour évaluer le pronostic d'une maladie connue. Des polypeptides, des polynucléotides et des anticorps de SPL sont également décrits.
Saba Julie D.
Zhou Jianhui
Children's Hospital & Research Center At Oakland
Children's Hospital Medical Center Of Northern California
Gowling Lafleur Henderson Llp
LandOfFree
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