C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2372541
The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.
La présente invention concerne généralement des molécules protéiques et leurs dérivés, analogues, équivalents chimiques et mimétiques pouvant moduler l'activité cellulaire et, en particulier, moduler l'activité cellulaire via la modulation de la transduction de signal. Elle concerne plus particulièrement une sphingosine kinase humaine ainsi que ses dérivés, analogues, équivalents chimiques et mimétiques. Elle concerne aussi des séquences géniques codant pour ces molécules protéiques et leurs dérivés, analogues, équivalents chimiques et mimétiques. Les molécules de la présente invention sont utiles dans un domaine d'applications thérapeutiques, prophylactiques et de diagnostics.
D'andrea Richard James
Gamble Jennifer Ruth
Pitson Stuart Maxwell
Vadas Mathew Alexander
Wattenberg Brian Wolff
Johnson & Johnson Pharmaceutical Research And Development Llc
Johnson & Johnson Research Pty. Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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