Sphingosomes for enhanced drug delivery

Details Sphingosomes for enhanced drug delivery Sphingosomes for enhanced drug delivery

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2193502

Liposomal formulations having extended circulation time (in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.

L'invention concerne des formulations de liposomes qui restent en circulation dans le corps pendant plus longtemps et qui retiennent mieux le médicament. Ces liposomes sont constitués de sphingomyéline et de cholestérol et le pH à l'intérieur de ces liposomes est acide. Les formulations sont plus stables, ce qui rend plus efficaces l'administration du médicament et le traitement. Leur utilisation permet d'améliorer d'une manière significative l'efficacité de l'administration de substances alcaloïdes, en particulier de la swainsonine, la vincristine et la vinblastine.

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