Sphks as modifiers of the p53 pathway and methods of use

Details Sphks as modifiers of the p53 pathway and methods of use Sphks as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12Q 1/02 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2454514

Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.

L'invention concerne des gènes humains de la sphingosine kinase (SPHK) qui sont identifiés en tant que modulateurs de la voie de passage p53, et qui sont donc des cibles thérapeutiques destinées à des troubles liés à une fonction p53 déficiente. Cette invention a aussi trait à des méthodes d'identification des modulateurs de p53 consistant à cribler des agents qui modulent l'activité de SPHK.

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