Spiro-2, 4-pyrimidinediamine compounds and their uses

Details Spiro-2, 4-pyrimidinediamine compounds and their uses Spiro-2, 4-pyrimidinediamine compounds and their uses

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/5386 (2006.01) A61P 37/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2584295

The present invention provides methods of treating or preventing autoimmune diseases with spiro 2,4-pyrimidinediamine compounds of Formula (I), as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

L'invention concerne des procédés de traitement ou de prévention de maladies auto-immunes par le biais de composés de spiro 2,4-pyrimidinediamine de formule (i), ainsi que des procédés de traitement, de prévention ou d'amélioration des symptômes associés à ces maladies. On cite des exemples spécifiques de maladies auto-immunes pour lesquelles il est possible d'envisager un traitement ou une prévention par le biais des composés décrits, à savoir polyarthrite rhumatoïde et/ou ses symptômes associés, lupus érythémateux systémique et/ou ses symptômes associés, et sclérose en plaques et/ou ses symptômes associés.

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