Spiro¬benzofuran-2(3h),1'-cycloheptane|s, a process and...

Details Spiro¬benzofuran-2(3h),1'-cycloheptane|s, a process and... Spiro¬benzofuran-2(3h),1'-cycloheptane|s, a process and...

C - Chemistry, Metallurgy

07

D

167/245, 260/361

C07D 307/94 (2006.01) A61K 31/34 (2006.01) C07D 407/12 (2006.01)

Patent

CA 1261341

ABSTRACT There are described compounds of the formula Image where each X is independently H, halogen, loweralkyl, loweralkoxy or OH; m is 1 or 2; and R is -H, =O, Image , =CH(CH2)nNR1CH3, -CH2(CH2)nNR1R2, =N-OH, =N-OCH2(CH2)nNR1R3, Image , =N-OCH2CHOHCH2NR1R3, -NR2R3, -OH or -OCH2(CH2)nNR1R2, n being 1 or 2, R1 being loweralkyl, R2 being H, loweralkyl, loweralkanoyl, arylloweralkyl, arylloweralkanoyl, diarylloweralkyl, diarylloweralkanoyl, -CO2C2H5 or -CN, and R3 being H, loweralkyl, arylloweralkyl or diarylloweralkyl, or a pharmaceutically acceptable acid addition salt thereof, which are useful as antihypertensive, anticonvulsant, analgesic and antidepressant agents. - 2 -

517492

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