Spiro bridged and unbridged heterocyclic compounds

Details Spiro bridged and unbridged heterocyclic compounds Spiro bridged and unbridged heterocyclic compounds

C - Chemistry, Metallurgy

07

D

167/225, 260/272

C07D 453/00 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) C07D 498/10 (2006.01) C07D 498/20 (2006.01) C07D 513/10 (2006.01)

Patent

CA 2039826

Compounds (I) and (II), including enantiomers, racemates and acid addition and quaternary salts, are for treating diseases of the central and peripheral nervous system, (see formula I and II) wherein in formula (I) Q is (CH2)m or C(CH3)2 attached to the 1',4' or 1',5' positions of the six-membered ring (m = 1, 2 or 3.) and in formula (II) Q is two hydrogen atoms, (CH2)m or C(CH3)2 (m = 1, 2 or 3) and n and p are each independently 0, 1, 2 or 3, provided that n + p = 2-3; R° is hydrogen, methyl or OH; (see formula III) is (see formula IV), (see formula V), (see formula VI or VII) R and R' are independently H, NH2, NH-C1-6-alkyl, N(C1-6-alkyl)2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7- cycloalkyl, C1-6- alkyl substituted by 1-6 halogen atoms, HO- C1-6-alkyl, C1-6- alkoxy, C1-6-alkylthio, C1-6-alkoxy-C1-6-alkyl, carboxy-C1-6- alkyl, (C1-6-alkoxy)carbonyl-C1-6-alkyl, amino-C1-6-alkyl, mono- (C1-6-alkyl)amino-C1-6-alkyl, di-(C1-6-alkyl)amino-C1-6-alkyl, 2- oxo-pyrrolidin-1-yl-methyl, Ar, di(Ar)methylol, or (Ar)1-2C1-6 alkyl, or R' may be C1-6-alkanoyl or Arcarbonyl; and Ar denotes Ph optionally substituted by 1-3 of halogen, C1-6-alkyl, C1-6- alkoxy and GF3, subject to certain provisos.

Affiliated with

Also associated with

Rating

Spiro bridged and unbridged heterocyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spiro bridged and unbridged heterocyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiro bridged and unbridged heterocyclic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2031879