Spiro compounds and methods for the modulation of chemokine...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/10 (2006.01) A61K 31/438 (2006.01)

Patent

CA 2579608

Compounds of formula I insert formula I from claim 1 wherein X, Y, Z, W, R1 and R2 as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.

L'invention concerne des composés de formule I (X, Y, Z, W, R¿1? et R¿2? sont tels que définis dans la description), ou des sels, hydrates, solvates correspondants pharmaceutiquement acceptables, utiles pour la modulation de l'activité du récepteur de chimiokine CCR5.

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