Spiro compounds for treatment of inflammatory disorders

Details Spiro compounds for treatment of inflammatory disorders Spiro compounds for treatment of inflammatory disorders

C - Chemistry, Metallurgy

07

D

C07D 493/10 (2006.01) A61K 31/35 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2686604

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of an inflammatory condition, in particular asthma. The compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof wherein Y, Z and R 1-R 12 are defined herein.

L'invention concerne des composés, des compositions pharmaceutiques et des procédés de traitement ou de prophylaxie d'un état inflammatoire, en particulier l'asthme. Les composés sont ceux de la Formule générale I, ou les sels pharmaceutiquement acceptables, esters, promédicaments ou dérivés de ceux-ci. Y, Z et R1-R12 de la Formule I sont définis présentement.

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