Spiro-condensed azetidine derivatives useful in treating...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/08 (2006.01) A61K 31/438 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2663500

Disclosed are compounds of the formula (I): and compounds of the formula (IIA): wherein R1, R2, R3, R4, R5, u and v are as defined herein. These compounds can be used in methods of treating pain (e.g., inflammatory pain, chronic pain, and neuropathic pain), methods of treating diabetes, and methods of inhibiting the absorption of cholesterol.

L'invention concerne des composés représentés par la formule (I) et des composés représentés par la formule (IIA), R1, R2, R3, R4, R5, u et v étant tels que définis dans les spécifications. Cette invention concerne aussi des procédés de traitement de la douleur (par exemple la douleur inflammatoire, douleur chronique et douleur nevropathique), des procédés de traitement du diabète et des procédés permettant d'inhiber l'absorption du cholestérol.

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