Spiro-containing compounds and compositions as modulators of...

C - Chemistry – Metallurgy – 07 – D

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C07D 489/04 (2006.01) A61K 31/397 (2006.01) A61K 45/06 (2006.01) C07D 263/52 (2006.01) C07D 489/10 (2006.01)

Patent

CA 2598878

Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent diseases or conditions associated with the activity of steroid hormone nuclear receptors.

La présente invention a trait à des composés présentant une élément structurel spiro. L'invention a également trait à des procédés pour la production de tels composés, à des procédés d'utilisation de tels composés pour la modulation de l'activité des récepteurs nucléaires des hormones stéroïdes, et à des compositions pharmaceutiques et des médicaments comportant de tels composés. L'invention a trait en outre à des procédés d'utilisation de tels composés, compositions pharmaceutiques et médicaments pour le traitement et/ou la prévention de maladies ou conditions associées à l'activité des récepteurs nucléaires des hormones stéroïdes.

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