C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/12 (2006.01) A61K 31/397 (2006.01) C07D 307/94 (2006.01) C07D 317/72 (2006.01) C07D 319/08 (2006.01) C07D 339/06 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2439539
The present application describes novel spiro-cyclic .beta.-amino acid derivatives of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3- 11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-.alpha. converting enzyme (TACE), and/or aggrecanase inhibitors.
La présente invention concerne des nouveaux dérivés de .beta.-aminoacides spirocycliques de formule (I) ou des formes salines pharmaceutiquement acceptables desdits composés. Dans cette formule, le noyau B est un carbocycle ou un hétérocycle de 3 à 13 éléments, le noyau C forme un spiro-carbocycle ou un spiro-hétérocycle sur le noyau B, et les autres variables sont telles que définies dans la description. Ces dérivés sont utiles comme inhibiteurs des métalloprotéinases matricielles (MPM), de l'enzyme de conversion de TNF-.alpha. et/ou de l'aggrécanase.
Chen Xiaotao
Duan Jingwu
Ott Gregory R.
Voss Matthew E.
Bristol-Myers Squibb Company
Dimock Stratton Llp
LandOfFree
Spiro-cyclic beta-amino acid derivatives as inhibitors of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Spiro-cyclic beta-amino acid derivatives as inhibitors of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiro-cyclic beta-amino acid derivatives as inhibitors of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1541974