C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 1/04 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2480039
Use of adhesion molecule inhibitors which are useful in preventing and treating inflammatory diseases caused by the infiltration of leukocytes such as monocytes, lymphocytes and eosinophils by inhibiting cell infiltration mediated by adhesion molecules, in particular, adhesion molecule VLA-4. Spiro derivatives which have an excellent effect of inhibiting cell adhesion mediated by adhesion molecules, in particular, adhesion molecule VLA-4 and, therefore, are useful as remedies for various inflammatory diseases. For example, a spiro derivative represented by the following formula (18) and adhesion molecule inhibitors comprising the same as the active ingredient are provided.
L'invention concerne l'utilisation d'inhibiteurs de molécules d'adhésion lesquels sont utiles dans la prévention et dans le traitement de maladies inflammatoires provoquées par l'infiltration de leucocytes tels que les monocytes, les lymphocytes et les éosinophiles par inhibition de l'infiltration cellulaire médiée par des molécules d'adhésion, en particulier, la molécule d'adhésion VLA-4. L'invention concerne également des dérivés spiro présentant un excellent effet d'inhibition de l'adhésion cellulaire médiée par des molécules d'adhésion, en particulier, la molécule d'adhésion VLA-4 et, par conséquent, utiles en tant que remèdes contre diverses maladies inflammatoires. Par exemple, l'invention concerne un dérivé spiro représenté par la formule (18) et des inhibiteurs de molécules d'adhésion le contenant en tant que principe actif.
Ishigaki Takeshi
Ishizaka Yoko
Kainoh Mie
Meguro Hiroyuki
Taniguchi Koji
Smart & Biggar
Toray Industries Inc.
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