Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one...

Details Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one... Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one...

C - Chemistry, Metallurgy

07

D

C07D 471/20 (2006.01) A61K 31/4747 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2666143

This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein j, k, m, Q, X,, R1, R2a, R2b, R2c, R2d and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, N-oxide, solvate or prodrug thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

La présente invention concerne des procédés d'utilisation de composés de spiro-oxindole de formule (I) : dans laquelle j, k, m, Q, X,, R1, R2a, R2b, R2c, R2d et R3 sont tels que définis ici, en tant que stéréoisomère, énantiomère, tautomère de ceux-ci ou que mélanges de ceux-ci; ou un sel, un N-oxyde, un solvate ou un promédicament pharmaceutiquement acceptable de ceux-ci, pour le traitement et/ou la prévention de maladies ou d'affections induites par les canaux sodiques telles que la douleur.

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