Spiro-ketal derivatives and their use as therapeutic agents

Details Spiro-ketal derivatives and their use as therapeutic agents Spiro-ketal derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 498/10 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/695 (2006.01) C07D 498/20 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2245578

The present invention relates to compounds of formula (I), wherein R represents hydroxy, C1-6alkoxy, C3-6alkenyloxy, C3-6alkynyloxy, fluoro C1- 6alkoxy, C3-7cycloalkoxy, C3-7cycloalkylC1-4alkoxy, phenoxy, benzyloxy or halogen, wherein the phenyl moiety of said phenoxy or benzyloxy is optionally substituted by one, two or three of C1-6alkyl, C1-6alkoxy, halogen and trifluoromethyl; R1, R2, R3, R4, R5, R6, R9a and R9b are as defined in the specification; or R and R1 may be joined such that -R-R1- is a linkage selected from -O-CH2- and -O-CH2CH2-; m is zero, 1, 2 or 3; and n is zero, 1, 2 or 3; with the proviso that the sum total of m and n is 2 or 3; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.

La présente invention se rapporte à des composés représentés par la formule (I) dans laquelle R est hydroxy, alcoxy C¿1-6?, alcényloxy C¿3-6?, alcynyloxy C¿3-6?, fluoro alcoxy C¿1-6?, cycloalcoxy C¿3-7?, cycloalkyle C¿3-7? alcoxy C¿1-4?, phénoxy, benzyloxy ou halogène, la fraction phényle dudit phénoxy ou dudit benzyloxy étant éventuellement substituée par un, deux ou trois composés sélectionnés parmi un alkyle C¿1-6?, un alcoxy C¿1-6?, un halogène et un trifluorométhyle, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?9a¿ et R?9b¿ sont tels que définis dans le descriptif de l'invention, ou bien R et R?1¿ peuvent être liés de façon à ce que -R-R?1¿- soit une liaison sélectionnée parmi -O-CH¿2?- et -O-CH¿2?CH¿2?-, m est égal à 0, 1, 2 ou 3 et n est égal à 0, 1, 2 ou 3 à condition que la somme de m et n soit égale à 2 ou 3. L'invention se rapporte également à des sels pharmaceutiquement acceptables de ces composés. Lesdits composés sont particulièrement utiles au traitement ou à la prévention de la douleur, de l'inflammation, de la migraine, des vomissements et de la névralgie postherpétique.

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