C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/20 (2006.01) A61K 31/407 (2006.01) A61P 29/00 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2604115
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
L'invention se rapporte à des composés de spiro-oxindole représentés par la formule (I) dans laquelle k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, et R3d sont tels que définis ci-après, en tant que stéréoisomère, enantiomère, tautomère ou mélanges de ceux-ci ; ou à un sel, un solvant ou un promédicament de ceux-ci pharmaceutiquement acceptable, qui sont utiles pour le traitement et/ou la prévention de maladies ou conditions à médiation de canal sodique, telles que la douleur. L'invention porte aussi sur des compositions pharmaceutiques contenant ces composés et sur des procédés de préparation et d'utilisation desdits composés.
Bagherzadeh Mehran Seid
Chafeev Mikhail
Chakka Nagasree
Chowdhury Sultan
Fraser Robert
Gowling Lafleur Henderson Llp
Xenon Pharmaceuticals Inc.
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