Spiro-polycyclicimidazolidinedione derivatives

Details Spiro-polycyclicimidazolidinedione derivatives Spiro-polycyclicimidazolidinedione derivatives

C - Chemistry, Metallurgy

07

D

260/305.3

C07D 235/02 (2006.01) C07D 491/10 (2006.01) C07D 495/10 (2006.01)

Patent

CA 1125294

ABSTRACT OF THE DISCLOSURE Novel spiro-polycyclicimidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include 2',3'-dihydro-spirolimidazolidine-4,4'- [4'H]-naphtho[1,2-b]pyran]-2,5-dione, 2',3'-dihydro-spiro[imidazoli- dine-4,4'-[4'H]-naphtho[1,-b]thiopyran-2,5-dione, 1',2',3',4'- tetrahydro-spiro[imidazolidine-4,1'benz[a]anthracene]-2,5-dione, 2',3'-dihydro-spiro[imidazolidine-4,1'-phenalene]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-phenanthrenel-2,5- dione, the 2,1 isomers of the 2',3'-dihydro-4'H-pyran and 2',3'- dihydro-4'H-thiopyran derivatives, the 2',3'-dihydro-4'H- anthracenopyran and 2',3'-dihydro-4'H-anthracenothiopyran derivatives, the spiro-4,4' isomer of the tetrahydrophenanthrene derivative, the [b] isomer of the benzanthracene derivative and the mono or disubstituted 2',3' dihydro-4'H-naphthopyran, 2',3'- dihydro-4'H-naphthothiopyran and tetrahydrophenanthrene derivatives. The novel compounds correspond generally to the formula Image I wherein A is nayhth-.alpha.,.beta.-o of formula III III Image anthracen-.alpha.,.beta.-o of formula IV Image IV or substituted naphth-.alpha.,.beta.-o having 1 or 2 identical substituents selected from methyl, chloro or bromo; and Y is CH2, S, SO, SO2 or O; or A and Y taken together are naphth-.alpha.,.beta.-o of the formula Image V

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