Spiro-substituted azacycles as neurokinin antagonists

Details Spiro-substituted azacycles as neurokinin antagonists Spiro-substituted azacycles as neurokinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/395 (2006.01) C07D 471/20 (2006.01) C07D 487/10 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01) C07D 491/20 (2006.01) C07D 495/10 (2006.01) C07D 495/20 (2006.01) C07D 513/10 (2006.01) C07D 513/20 (2006.01)

Patent

CA 2163995

Disclosed are spiro-substituted azacycles of formula (I), tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma. In particular compounds of formula (I) are shown to be neurokinin antagonists.

Azacycles spirosubstitués de la formule I, antagonistes des récepteurs de la tachykinine, utiles dans le traitement de maladies inflammatoires, de la douleur ou de la migraine et de l'asthme. Et, en particulier, composés de la formule (I) s'avérant antagonistes de la neurokinine.

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