Spiro-substituted azacycles as tachykinin receptor antagonists

Details Spiro-substituted azacycles as tachykinin receptor antagonists Spiro-substituted azacycles as tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 221/20 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01) C07D 495/20 (2006.01)

Patent

CA 2154569

Disclosed are spiro-substituted azacycles of formula (I), are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, emesis and asthma. In particular compounds of formula (I) are shown to be neurokinin antagonists.

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