Spiro-substituted cyclic amines of quinolone derivatives

Details Spiro-substituted cyclic amines of quinolone derivatives Spiro-substituted cyclic amines of quinolone derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/271

C07D 401/10 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07D 498/06 (2006.01)

Patent

CA 1336090

A compound of formula I, having antibacterial activity and a pharmaceutical composition containing the compound of formula I: Image I wherein a represents an integer equal to 0 or 1; b represents an integer equal to 2 through 5, inclusive; c represents an integer equal to 0 or 1; and d repre- sents an integer equal to 0 through 2, inclusive; Z represents Image , Image , Image , an oxygen atom or a sulfur atom, wherein R1 represents a hydrogen atom, an amino group, a monoalkylamino group of 1 to 6 carbon atoms, a dialkylamino group containing 1 to 6 carbon atoms per alkyl, a hydroxyl group, an alkoxy group of 1 to 6 carbon atoms or a hydroxyalkyl group of 1 to 6 carbon atoms; R2 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a hydroxyalkyl group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, a formyl group or an alkylcarbonyl group of 2 to 7 carbon atoms; and R3 represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; Q represents a partial structure of formula II: Image II wherein R4 represents an alkyl group of 1 to 6 carbon atoms, an alkenyl group of 2 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, a substituted or unsubstituted cycloalkyl group of 3 to 6 carbon atoms, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, an alkoxy group of 1 to 6 carbon atoms or an alkylamino group of 1 to 6 carbon atoms; R5 represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; R6 represents a hydrogen atom, a substituted or unsubstituted amino group, a hydroxyl group, an alkoxy group of 1 to 6 carbon atoms or a halogen atom; A represents a nitrogen atom or Image , wherein R7 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a halogen atom, an alkoxy group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms or a cyano group; R4 may, taken together with R5 and/or R7, form a substituted or unsubstituted ring which can include an oxygen, nitrogen or sulfur atom, wherein the substituent is an alkyl group of 1 to 6 carbon atoms or a haloalkyl group of 1 to 6 carbon atoms; X represents a halogen atom; Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, an alkoxyalkyl group of 1 to 6 carbon atoms, a phenylalkyl group containing 1 to 6 carbon atoms in its alkyl moiety, a dihaloboron group, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyloxy group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-substituted-2-oxo-1,3-dioxazol- 4-ylmethyl group or a 3-acetoxy-2-oxobutyl group, or a salt thereof.

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