Spiroaminodihydrothiazine derivatives

Details Spiroaminodihydrothiazine derivatives Spiroaminodihydrothiazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 513/10 (2006.01) A61K 31/547 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2731209

A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof, has an A.beta. production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by A.beta. and typified by Alzheimer- type dementia.

L'invention porte sur un composé représenté par la formule générale (I) ou sur un sel pharmaceutiquement acceptable de celui-ci, qui a un effet inhibiteur de la production de Aß ou un effet inhibiteur de BACE1 et est utile comme agent prophylactique ou thérapeutique pour une maladie neurodégénérative provoquée par Aß et caractérisée par la démence de type Alzheimer.

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