Spirocyclic aminoquinolones as gsk-3 inhibitors

Details Spirocyclic aminoquinolones as gsk-3 inhibitors Spirocyclic aminoquinolones as gsk-3 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 498/10 (2006.01) A61K 31/4747 (2006.01) A61P 25/00 (2006.01) C07D 498/20 (2006.01)

Patent

CA 2699152

Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK- 3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.

L'invention concerne des aminoquinolones spirocycliques de formule I et des compositions contenant ces composés. Les composés et les compositions proposées sont utiles dans la prévention, l'amélioration ou le traitement des maladies induites par les inhibiteurs de GSK-3. Dans la formule (I): X1 représente O ou NR8; A représente une liaison ou un alcylène C1-C2 substitué ou non substitué, les substituants éventuels étant choisis entre un à quatre groupes Q2, Q2représentant alkyle ou haloalkyle; p représente 0 ou 1, et q est un nombre entier valant de 0 à 2.

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