Spirocyclic heterocyclic derivatives and methods of their use

Details Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/407 (2006.01) A61K 31/438 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 221/20 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2603126

Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the .delta. opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other .delta. opioid receptor-mediated conditions.

L'invention porte sur des dérivés spirocycliques hétérocycliques, sur des compositions pharmaceutiques contenant lesdits composés et sur des procédés d'utilisation pharmaceutique de ces derniers. Dans certains modes de réalisation, les dérivés spirocycliques hétérocycliques de l'invention sont des ligands du récepteur opioïde d et peuvent être utilisés, entre autres, pour traiter et/ou empêcher la douleur, l'anxiété, les troubles gastro-intestinaux et autres états médiés par le récepteur opioïde d.

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