C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/107 (2006.01) A61K 31/438 (2006.01) C07D 221/20 (2006.01) C07D 491/20 (2006.01)
Patent
CA 2541014
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the .delta. opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other .delta. opioid receptor-mediated conditions.
L'invention concerne des dérivés hétérocycliques spirocycliques, des compositions pharmaceutiques contenant ces composés, et leurs méthodes d'utilisation pharmaceutique. Dans certains modes de réalisation, ces dérivés hétérocycliques spirocycliques sont des ligands du récepteur opioïde .delta. et peuvent être utiles, entre autres, pour le traitement et/ou la prévention de la douleur, de l'anxiété, de troubles gastro-intestinaux et d'autres états médiés par le récepteur opioïde .delta..
Ajello Christopher W.
Chu Guo-Hua
Dolle Roland E.
Gu Minghua
Le Bourdonnec Bertrand
Adolor Corporation
Gowling Lafleur Henderson Llp
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