Spirocyclic quinazoline derivatives and their use as pde7...

Details Spirocyclic quinazoline derivatives and their use as pde7... Spirocyclic quinazoline derivatives and their use as pde7...

C - Chemistry, Metallurgy

07

D

C07D 239/70 (2006.01) A61K 31/527 (2006.01) A61P 29/00 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2687944

This invention relates to spirocyclic derivatives, compositions containing and the uses of, such derivatives. The spirocyclic derivatives of the present invention are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain. The invention provides a compound of formula (I): wherein: X is O. S or N-CN; R1 is halogen or CN; A is a single bond, CH2, 0 or S; B is a single bond, CH2 or OCH2; each R2 is independently halogen, (C1-6)alkyl (optionally substituted by 1 to 3 fluorine atoms), OH, (C1-6)aIkOXy, (C1-6)alkytthio or CN; R3 is selected from the following groups (i) to (x).

L'invention porte sur des composés représentés par la formule (I), dans laquelle m, n, X, R1, A, B, R2 et R3 ont les significations données dans la description, et sur leurs sels pharmaceutiquement acceptables, solvates, polymorphes et promédicaments. Les composés sont des inhibiteurs de PDE7 et ont un nombre d'applications thérapeutiques, en particulier dans le traitement de la douleur, notamment de la douleur névropathique.

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