Spirocyclic quinazoline derivatives as pde7 inhibitors

Details Spirocyclic quinazoline derivatives as pde7 inhibitors Spirocyclic quinazoline derivatives as pde7 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01) A61K 31/522 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2631535

The invention provides compounds of formula (I): (I) wherein: m is 0, 1 or 2; X is O, S or N-CN; R is F, Cl or CN; A is a C3-6 cycloalkylene group optionally substituted with a C1-4 alkyl group; and B is a single bond or a C1- 2alkylene group; or a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain.

L'invention concerne des composés de formule (I) dans laquelle: m prend la valeur de 0, 1 ou 2; X représente O, S ou N-CN; R représente F, Cl ou CN; A représente un groupe cycloalkylène en C3-6 éventuellement substitué par un groupe alkyle en C1-4; et B représente une liaison simple ou un groupe alkylène en C1-2; ou un sel, un solvate, un polymorphe ou un promédicament de ceux-ci acceptable sur le plan pharmaceutique. Les composés consistent en des inhibiteurs de PDE7 et possède un certain nombre d'applications thérapeutiques, en particulier dans le traitement de la douleur, notamment la douleur neuropathique.

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