C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/475 (2006.01) A61P 35/02 (2006.01) C07D 411/14 (2006.01) C07D 471/10 (2006.01) C07D 487/10 (2006.01) C07D 491/10 (2006.01) C07D 495/10 (2006.01)
Patent
CA 2581150
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, R1, X and Y are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
L~invention concerne des composés représentés par la formule (I) : dans laquelle A, R1, X et Y sont tels que définis ici, ou un sel acceptable du point de vue pharmaceutique ou N-oxyde de celui-ci, qui sont utiles dans le traitement de tumeurs et de cancers tels que la mastocytose/leucémie à mastocytes, les tumeurs stromales gastro-intestinales (GIST), les tumeurs à cellules reproductrices, le cancer du poumon à petites cellules (SCLC), le lymphome à cellules T/tueuses naturelles sinonasales, le cancer des testicules (séminome), le cancer de la thyroïde, le mélanome malin, le cancer des ovaires, le cancer kystique adénoïde, la leucémie myéloïde aiguë (AML), le cancer du sein, la leucémie lymphoblastique aiguë à cellules T pédiatrique, le neuroblastome, la leucémie à mastocytes, l'angiosarcome, le lymphome anaplasique à grandes cellules, le cancer de l'endomètre et le cancer de la prostate.
Dong Hanqing
Li An-Hu
Zhang Tao
Cassan Maclean
Osi Pharmaceuticals Inc.
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