C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/107 (2006.01) A61K 31/435 (2006.01) C07D 491/10 (2006.01) C07D 491/20 (2006.01)
Patent
CA 2150947
Compounds of formula (I), wherein ring A is a ring of formula (AI) or (AII) (in which the spiro atom is indicated by *), R1 represents H or alkyl C1-6; represents -(CH2)n-OR3, -(CH2)m-C(O)R4, fluoroalkyl C1-6, cyanoalkyl C1-6 or alkyl C1-6 substituted with a 4-7 membered optionally unsaturated heterocycle ring; R3 represents H, alkyl C1-6 (optionally substituted with alkoxy C1-6), cycloalkyl C4-7, a 4-7 membered optionally unsaturated heterocyclic ring, phenyl (optionally substituted with halogen, hydroxy or alkyl C1-6), or benzyl (optionally substituted with halogen, hydroxy or alkyl C1-6); R4 represents OR5, NR6R7, N(OR6)R7 or alkyl C1-6; R5 represents H, alkenyl C2-6, alkynyl C2-6 or alkyl C1-6) optionally substituted with phenyl); R6 and R7 independently represent H or alkyl C1-6; R5 represents H, alkenyl alkyl C1-6; n is 2-5; m is 1-5; p is 1 or 2; and pharmaceutically acceptable salts thereof; are useful in the treatment of neurodegenerative disorders.
Kover Alexander
Loch James III
Mullen George
Wu Edwin Shen-Chou
Astra Ab
Ridout & Maybee Llp
LandOfFree
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