C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/4468 (2006.01) A61K 31/517 (2006.01) A61K 31/536 (2006.01) A61K 31/5377 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 37/00 (2006.01) C07D 211/66 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2417177
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.
La présente invention concerne de nouveaux composés inhibiteurs réversibles de cathépsines S, K, L et B représentés par les formules (Ia) et (Ib). Dans ces formules R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, Het et X sont tels que définis dans les spécifications. Ces composés conviennent pour traiter des maladies auto-immunes et d'autres maladies. Cette invention concerne aussi des processus de fabrication de ces nouveaux composés.
Bekkali Younes
Hickey Eugene R.
Liu Wiemin
Patel Usha R.
Spero Denice M.
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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