Spiroindolinone derivatives as anticancer agents

Details Spiroindolinone derivatives as anticancer agents Spiroindolinone derivatives as anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/4747 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2708312

There are provided compounds of the formula (I) and pharmaceutically acceptable salts, esters and enantiomers thereof, wherein W, X, X', Y, V, V', A, B and R are as described herein; processes for making such compounds and methods for using them. The compounds have utility as antiproliferative agents, especially, as anticancer agents.

La présente invention concerne des composés de formule (I) et les sels pharmaceutiquement acceptables, les esters et les énantiomères de ceux-ci. Dans cette formule, W, X, X', Y, V, V', A, B et R sont tels que décrits dans le présent document. L'invention concerne aussi un procédé de fabrication de ces composés et des procédés d'utilisation de ceux-ci. Les composés sont utiles en tant qu'agents anti-prolifératifs, notamment, en tant qu'agents anticancéreux.

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