C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/10 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/695 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2207653
The present invention relates to spiroketal derivatives of formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R9a, R9b, m and n are as defined in the specification, and to processes for their preparation, to intermediates used in their synthesis, to pharmaceutical compositions containing them, and to their use in therapy. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
Dérivés de la spirochétose de formule (I) et leurs sels de qualité pharmaceutique, dans lesquels R1, R2, R3, R4, R5, R6, R9a, R9b, m et n sont tels que définis dans la spécification; leur mode de préparation, les intermédiaires utilisés dans leur synthèse, les compositions pharmaceutiques les contenant, et leur utilisation à des fins thérapeutiques. Les composés servent notamment dans le traitement ou la prévention de la douleur, de l'inflammation, des migraines, des vomissements et de la névralgie postherpétique.
Harrison Timothy
Owen Simon Neil
Seward Eileen Mary
Swain Christopher John
Merck Sharp & Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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