C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/438 (2006.01)
Patent
CA 2662776
The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
La présente invention concerne des composés de spiropipéridine représentés par la formule (I) et des tautomères de ces derniers, étant des inhibiteurs de l'enzyme bêta-sécrétase et étant utiles dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est mise en jeu, telles que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est mise en jeu.
Barrow James C.
Coburn Craig A.
Egbertson Melissa S.
Fahr Bruce
Lu Wanli
Merck And Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Sunesis Pharmaceuticals Inc.
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