Spiropiperidine beta-secretase inhibitors for the treatment...

Details Spiropiperidine beta-secretase inhibitors for the treatment... Spiropiperidine beta-secretase inhibitors for the treatment...

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2668065

The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

La présente invention concerne des composés de spiropipéridine de formule (I) qui sont des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utilisés dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée, par exemple la maladie d'Alzheimer. L'invention concerne également les compositions pharmaceutiques qui comprennent ces composés et l'utilisation de ces composés et de ces compositions dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée.

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